Using Atipamezole as an Antidote

Did you know that atipamezole (Antisedan®) can be used for more than just reversing dexmedetomidine (Dexdomitor®)? 

In fact, it is often very useful for reversing intoxications caused by a2 adrenergic agonists, which can be found in prescription medications and over-the-counter products ranging from flea collars to eye drops. For example amitraz, xylazine, imidazoline decongestants (often found in eye drops), tizanidine, and clonidine.

Atipamezole will reverse sedation, bradycardia, and hypotension caused by a2-adrenergic agonists. 

The effects of atipamezole are very rapid and drastic improvement in blood pressure, heart rate and mentation are often seen very quickly after administration. 

The effects of atipamezole typically last two to three hours, which can be significantly shorter than the agents it is reversing; therefore, multiple doses may be indicated based on clinical signs that the animal is exhibiting (especially recurrence of significant cardiovascular signs). 

Atipamezole is preferred over yohimbine as it is a more specific a2-adrenergic antagonist.